In vitro effects of suramin on Trypanosoma cruzi

被引：21

作者：

Bisaggio, Danielle Frias Ribeiro ^{[2
]}

Adade, Camila Marques ^{[1
]}

Souto-Padron, Thais ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Microbiol Prof Paulo Goes, BR-21941902 Rio De Janeiro, Brazil

[2] Fiocruz MS, Inst Oswaldo Cruz, Rio De Janeiro, Brazil

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2008年 / 31卷 / 03期

关键词：

suramin; Trypanosoma cruzi; ultrastructure; parasite-host cell interaction;

D O I：

10.1016/j.ijantimicag.2007.11.001

中图分类号：

R51 [传染病];

学科分类号：

100401 [流行病与卫生统计学];

摘要：

Suramin has been previously reported to inhibit distinct cellular enzymes and to affect the synthesis and distribution of cytoskeleton proteins, cell differentiation and proliferation. The present study indicates that prolonged incubation of Trypanosoma cruzi-infected cells in the presence of 500 mu M suramin during intracellular development of the parasite causes morphological changes in amastigote and trypomastigote forms related to the cell division and differentiation process. Our results also show that trypomastigotes obtained from suramin-treated host cells were significantly less infective than control parasites and that amastigotes derived from those trypomastigote forms were less proliferative. (C) 2007 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：282 / 286

页数：5

共 15 条

[1]

Effect of suramin on trypomastigote forms of Trypanosoma cruzi:: Changes on cell motility and on the ultrastructure of the flagellum-cell body attachment region [J].

Bisaggio, Danielle F. R. ;

Campanati, Loraine ;

Pinto, Rodrigo C. V. ;

Souto-Padron, Thais .

ACTA TROPICA, 2006, 98 (02) :162-175

[2]

Ecto-ATPase activity on the surface of Trypanosoma cruzi and its possible role in the parasite-host cell interaction [J].

Bisaggio, DFR ;

Peres-Sampaio, CE ;

Meyer-Fernandes, JR ;

Souto-Padrón, T .

PARASITOLOGY RESEARCH, 2003, 91 (04) :273-282

[3]

Ablation of the single dynamin of T-brucei blocks mitochondrial fission and endocytosis and leads to a precise cytokinesis arrest [J].

Chanez, Anne-Laure ;

Hehl, Adrian B. ;

Engstler, Markus ;

Schneider, Andre .

JOURNAL OF CELL SCIENCE, 2006, 119 (14) :2968-2974

[4]

CELL BIOLOGY OF TRYPANOSOMA-CRUZI [J].

DESOUZA, W .

INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY, 1984, 86 :197-283

[5]

SUSCEPTIBILITY AND NATURAL-RESISTANCE OF TRYPANOSOMA-CRUZI STRAINS TO DRUGS USED CLINICALLY IN CHAGAS-DISEASE [J].

FILARDI, LS ;

BRENER, Z .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1987, 81 (05) :755-759

[6]

Hawking F, 1978, Adv Pharmacol Chemother, V15, P289, DOI 10.1016/S1054-3589(08)60486-X

[7]

HAWKING F, 1960, J CELL SCI, V15, P567

[8]

Suramin's development: What did we learn? [J].

Kaur, M ;

Reed, E ;

Sartor, O ;

Dahut, W ;

Figg, WD .

INVESTIGATIONAL NEW DRUGS, 2002, 20 (02) :209-219

[9]

Evidence for a non-LDL-mediated entry route for the trypanocidal drug suramin in Trypanosoma brucei [J].

Pal, A ;

Hall, BS ;

Field, MC .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2002, 122 (02) :217-221

[10]

SEAH S, 1970, J TROP MED HYG, V73, P170

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