Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study

被引:179
作者
Bramon, E
McDonald, C
Croft, RJ
Landau, S
Filbey, F
Gruzelier, JH
Sham, PC
Frangou, S
Murray, RM
机构
[1] Inst Psychiat, London SE5 8AF, England
[2] Swinburne Univ Technol, Brain Sci Inst, Hawthorn, Vic 3122, Australia
[3] NIMH, Bethesda, MD 20892 USA
[4] Univ London Imperial Coll Sci Technol & Med, Div Neurosci & Psychol Med, London W6 8RF, England
基金
英国惠康基金;
关键词
P300; meta-analysis; endophenotype; schizophrenia; psychosis; genetic;
D O I
10.1016/j.neuroimage.2005.05.022
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We assessed the usefulness of the P300 wave as endophenotype for schizophrenia by means of a meta-analysis of the literature as well as our own family study. Method: Meta-analysis: We conducted a systematic search for articles published between 1983 and 2003 that reported P300 measures in nonpsychotic relatives of schizophrenic patients and in healthy controls. Meta-regression analyses were performed using a random effects procedure. The pooled standardized effect size (PSES) was calculated as the difference between the means of the two groups divided by the common standard deviation. Local study: We examined the P300 wave with a standard two-tone oddball paradigm in 30 patients with schizophrenia, 40 non-psychotic relatives, and 40 controls using linear mixed models. Results: Meta-analysis: We pooled 472 relatives and 513 controls. The P300 amplitude was significantly reduced in relatives (PSES = 0.61; 95% Cl: 0.30 to 0.91; P < 0.001). The P300 latency was significantly delayed in relatives (PSES of-0.50; 95% Cl: -0.88 to -0.13; P=0.009]. Local study: The patients showed a trend for amplitude reductions (P = 0.06) and significant latency delays (P < 0.01). The relatives displayed normal amplitude but had significant latency delays (P = 0.01). The P300 amplitude and especially the P300 latency are promising alternative phenotypes for genetic research into schizophrenia. (C) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:960 / 968
页数:9
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