Regional differences in predictive accuracy of WHO immunologic failure criteria

被引：6

作者：

Kiragga, Agnes N. ^{[1
]}

Castelnuovo, Barbara ^{[1
]}

Kamya, Moses R. ^{[1
,2
]}

Moore, Richard ^{[3
,4
]}

Manabe, Yukari C. ^{[1
,3
,4
]}

机构：

[1] Makerere Univ, Infect Dis Inst, Coll Hlth Sci, Kampala, Uganda

[2] Makerere Univ, Dept Med, Coll Hlth Sci, Kampala, Uganda

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Div Infect Dis, Baltimore, MD USA

[4] Johns Hopkins Bloomberg Sch Publ Hlth, Div Clin Pharmacol, Baltimore, MD USA

来源：

AIDS | 2012年 / 26卷 / 06期

基金：

英国惠康基金;

关键词：

ANTIRETROVIRAL TREATMENT FAILURE; AFRICAN COHORT; THERAPY; RESISTANCE; SUBTYPE; HIV-1; INFECTION; UGANDA; ADULTS;

D O I：

10.1097/QAD.0b013e32835143e3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We compared the performance of the WHO immunologic criteria for treatment failure among Uganda and American patients. Antiretroviral treatment-naive patients with a CD4 T-cell count less than 200 cells/mu l or AIDS at enrollment on a nonnucleoside reverse transcriptase inhibitors-based regimen for more than 1 year were selected. For all criteria, the positive predictive value was significantly higher in the American compared with the Ugandan patients. Population-specific guidelines should be developed using large African cohorts to identify more specific and sensitive criteria.

引用

页码：768 / 770

页数：3

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