An unexpected inversion of enantioselectivity in the proline catalyzed intramolecular Baylis-Hillman reaction

被引：122

作者：

Chen, SH

Hong, BC ^{[1
]}

Su, CF

Sarshar, S

机构：

[1] Natl Chung Cheng Univ, Dept Chem & Biochem, Chiayi 621, Taiwan

[2] Auspex Pharmaceut Inc, Vista, CA 92081 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 51期

关键词：

Baylis-Hillman; proline; intramolecular; inversion;

D O I：

10.1016/j.tetlet.2005.10.072

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly enantioselective proline catalyzed intramolecular Baylis-Hillman reaction of hept-2-enedial is reported. Addition of imidazole to the mixture results in art unusual inversion of enantioselectivity. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：8899 / 8903

页数：5

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