An unexpected inversion of enantioselectivity in the proline catalyzed intramolecular Baylis-Hillman reaction

被引:122
作者
Chen, SH
Hong, BC [1 ]
Su, CF
Sarshar, S
机构
[1] Natl Chung Cheng Univ, Dept Chem & Biochem, Chiayi 621, Taiwan
[2] Auspex Pharmaceut Inc, Vista, CA 92081 USA
关键词
Baylis-Hillman; proline; intramolecular; inversion;
D O I
10.1016/j.tetlet.2005.10.072
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A highly enantioselective proline catalyzed intramolecular Baylis-Hillman reaction of hept-2-enedial is reported. Addition of imidazole to the mixture results in art unusual inversion of enantioselectivity. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:8899 / 8903
页数:5
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