The TRPV4 channel: structure-function relationship and promiscuous gating behaviour

被引：120

作者：

Nilius, B ^{[1
]}

Watanabe, H ^{[1
]}

Vriens, J ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Physiol, B-3000 Louvain, Belgium

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2003年 / 446卷 / 03期

关键词：

Ca2+ entry channels; TRP channels; structure-function relationship; mechano-sensors; temperature sensors;

D O I：

10.1007/s00424-003-1028-9

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Transient receptor potential (TRP) channels provide an enormous variability of Ca2+ influx mechanisms triggered by a wide range of stimuli. In this review, we discuss the activation properties of the Ca2+- and Mg2+-permeable TRP channel of the vanilloid subfamily TRPV4. This channel is activated by various physical and chemical stimuli, such as cell swelling, heat, phorbols and, probably, by endogenous ligands, which are able to induce Ca2+ entry. Not much is known about the regulation of this channel. We will refer only to a mechanism of Ca2+-dependent inhibition of TRPV4. Possible functional roles of this channel will be correlated with its observed expression pattern. Finally, we discuss the structural determinants of TRPV4 channel function.

引用

页码：298 / 303

页数：6

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