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Gut microorganisms, mammalian metabolism and personalized health care

被引：691
作者：
Nicholson, JK
Holmes, E
Wilson, ID
机构：
[1] Biomedical Sciences Division, Imperial College London, London SW7 2AZ, South Kensington
[2] Department of Drug Metabolism and Pharmacokinetics, AstraZeneca Pharmaceuticals, Macclesfield, Cheshire SK10 4TG, Mereside, Alderley Park
来源：
NATURE REVIEWS MICROBIOLOGY | 2005年 / 3卷 / 05期
基金：
英国惠康基金; 英国工程与自然科学研究理事会; 美国国家卫生研究院; 英国生物技术与生命科学研究理事会;
关键词：
D O I：
10.1038/nrmicro1152
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The mammalian gut microbiota interact extensively with the host through metabolic exchange and co-metabolism of substrates. Such metabolome-metabolome interactions are poorly understood, but might be implicated in the aetiology of many human diseases. In this paper, we assess the importance of the gut microbota in influencing the disposition, fate and toxicity of drugs in the host, and conclude that appropriate consideration of individual human gut microbial activities will be a necessary part of future personalized health-care paradigms.
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页码：431 / 438
页数：8
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