Facile p-toluenesulfonic acid-promoted para-selective monobromination and chlorination of phenol and analogues

被引：60

作者：

Bovonsombat, Pakorn ^{[1
]}

Ali, Rameez ^{[1
]}

Khan, Chiraphorn ^{[1
]}

Leykajarakul, Juthamard ^{[1
]}

Pla-on, Kawin ^{[1
]}

Aphimanchindakul, Suraj ^{[1
]}

Pungcharoenpong, Natchapon ^{[1
]}

Timsuea, Nisit ^{[1
]}

Arunrat, Anchalee ^{[1
]}

Punpongjareorn, Napat ^{[1
]}

机构：

[1] Mahidol Univ, Mahidol Univ Int Coll, Nakhon Pathom 73170, Thailand

来源：

TETRAHEDRON | 2010年 / 66卷 / 34期

关键词：

CROSS-COUPLING REACTIONS; AROMATIC-COMPOUNDS; REGIOSELECTIVE BROMINATION; NUCLEAR BROMINATION; N-BROMOSUCCINIMIDE; POTASSIUM-BROMIDE; TETRABUTYLAMMONIUM BROMIDE; HYDROGEN-PEROXIDE; REAGENT; MILD;

D O I：

10.1016/j.tet.2010.06.041

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

para-Regioselective bromination of phenol and analogues, promoted by p-toluenesulfonic acid, is achieved in high to excellent yields at room temperature with N-bromosuccinimide. Chlorination with N-chlorosuccinimide and catalysed by p-toluenesulfonic acid also gives para-chlorinated phenol analogues in good yields at room temperature. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6928 / 6935

页数：8

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