Molecular biology of Burkitt's lymphoma

被引：273

作者：

Hecht, JL

Aster, JC

机构：

[1] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2000年 / 18卷 / 21期

关键词：

D O I：

10.1200/JCO.2000.18.21.3707

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The diagnostic category of Burkitt's lymphoma encompasses a closely related group of aggressive B-cell tumors that includes sporadic, endemic, and human immunodeficiency virus-associated subtypes. All subtypes are characterized by chromosomal rearrangements involving the c-myc proto-oncogene that lead to its inappropriate expression. This review focuses on the roles of c-myc dysregulation and EpsreinBarr virus infection in Burkitt's lymphoma. Although the normal function of c-myc remains enigmatic, recent data indicate that it has a central role in several fundamental aspects of cellular biology, including proliferation, differentiation, metabolism, apoptosis, and telomere maintenance. We discuss new insights into the molecular mechanisms of these c-Myc activities and their potential relevance to the pathogenesis of Burkitt's lymphoma and speculate on the role of EpsteinBarr virus. (C) 2000 by American Society of Clinical Oncology.

引用

收藏

页码：3707 / 3721

页数：15

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