Molecular biology of Burkitt's lymphoma

被引：273

作者：

Hecht, JL

Aster, JC

机构：

[1] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2000年 / 18卷 / 21期

关键词：

D O I：

10.1200/JCO.2000.18.21.3707

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The diagnostic category of Burkitt's lymphoma encompasses a closely related group of aggressive B-cell tumors that includes sporadic, endemic, and human immunodeficiency virus-associated subtypes. All subtypes are characterized by chromosomal rearrangements involving the c-myc proto-oncogene that lead to its inappropriate expression. This review focuses on the roles of c-myc dysregulation and EpsreinBarr virus infection in Burkitt's lymphoma. Although the normal function of c-myc remains enigmatic, recent data indicate that it has a central role in several fundamental aspects of cellular biology, including proliferation, differentiation, metabolism, apoptosis, and telomere maintenance. We discuss new insights into the molecular mechanisms of these c-Myc activities and their potential relevance to the pathogenesis of Burkitt's lymphoma and speculate on the role of EpsteinBarr virus. (C) 2000 by American Society of Clinical Oncology.

引用

页码：3707 / 3721

页数：15

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