The role of autophagy induced by tumor microenvironment in different cells and stages of cancer

被引：134

作者：

Yang, Xue ^{[1
]}

Yu, Dan-Dan ^{[1
]}

Yan, Fei ^{[1
]}

Jing, Ying-Ying ^{[1
]}

Han, Zhi-Peng ^{[1
]}

Sun, Kai ^{[2
]}

Liang, Lei ^{[1
]}

Hou, Jing ^{[3
]}

Wei, Li-Xin ^{[1
]}

机构：

[1] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Tumor Immunol & Gene Therapy Ctr, Shanghai 200438, Peoples R China

[2] Shanghai Jiao Tong Univ, Ren Ji Hosp, Cent Lab, Sch Med, Shanghai 200030, Peoples R China

[3] Second Mil Med Univ, Chang Hai Hosp, Dept Pharm, Shanghai 200438, Peoples R China

来源：

CELL AND BIOSCIENCE | 2015年 / 5卷

基金：

中国国家自然科学基金;

关键词：

Autophagy; Tumor microenvironment; Tumorigenesis; MESENCHYMAL STEM-CELLS; DOUBLE-EDGED-SWORD; STROMAL CELLS; BONE-MARROW; PREVENT APOPTOSIS; OXIDATIVE STRESS; SURVIVAL ROLE; UP-REGULATION; IN-VITRO; HYPOXIA;

D O I：

10.1186/s13578-015-0005-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Development of a tumor is a very complex process, and invasion and metastasis of malignant tumors are hallmarks and are difficult problems to overcome. The tumor microenvironment plays an important role in controlling tumor fate and autophagy induced by the tumor microenvironment is attracting more and more attention. Autophagy can be induced by several stressors in the tumor microenvironment and autophagy modifies the tumor microenvironment, too. Autophagy has dual roles in tumor growth. In this review, we discussed the interaction between autophagy and the tumor microenvironment and the paradoxical roles of autophagy on tumor growth at different stages of tumor development.

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页数：11

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