A flexible and catalytic one-pot procedure for the synthesis of indoles

被引：128

作者：

Siebeneicher, H ^{[1
]}

Bytschkov, I ^{[1
]}

Doye, S ^{[1
]}

机构：

[1] Leibniz Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 26期

关键词：

alkynes; homogeneous catalysis; hydroamination; palladium; titanium;

D O I：

10.1002/anie.200351345

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One pot, two bonds, three rings: A clever combination of a [Cp2TiMe2]-catalyzed hydroamination of alkynes with a Pd-catalyzed N-arylation of imines results in a new and general method for the synthesis of indoles. Impressively, two new C-N bonds are formed during the one-pot procedure (see scheme).

引用

页码：3042 / 3044

页数：3

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