[1] Northeastern Univ, Sch Pharm, Boston, MA 02115 USA
[2] Inst Clin Res & Hlth Policy Studies, Data & Design Resource Ctr, Boston, MA USA
[3] Tufts Univ, New England Med Ctr, Med Intens Care Unit, Boston, MA 02111 USA
[4] Tufts Univ, Sch Med, Boston, MA 02111 USA