The mitochondrial voltage-dependent anion channel (VDAC) as a therapeutic target for initiating cell death

被引：46

作者：

Granville, DJ ^{[1
]}

Gottlieb, RA ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2003年 / 10卷 / 16期

关键词：

mitochondria; apoptosis; VDAC; heart; cytochrome c; cell death; Bcl-2; Bax;

D O I：

10.2174/0929867033457214

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Voltage-dependent anion channels (VDAC) are major constituents of the outer mitochondrial membrane. Over the past few years, several hypotheses and mechanisms have been forwarded for and against a role for VDAC in outer mitochondrial membrane permeability and the subsequent release of apoptosis promoting factors. The current review outlines current knowledge related to the role of VDAC in the regulation of cell death and speculates on possible therapeutic applications through VDAC modulation.

引用

页码：1527 / 1533

页数：7

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