Otologic Manifestation in IgG4-Related Systemic Disease

被引:35
作者
Cho, Han-Kyu [4 ]
Lee, Yun Jong [2 ]
Chung, Jin-Haeng [3 ]
Koo, Ja-Won [1 ,5 ]
机构
[1] Seoul Natl Univ, Bundang Hosp, Dept Otorhinolaryngol, Coll Med, Songnam 463707, South Korea
[2] Seoul Natl Univ, Bundang Hosp, Dept Rheumatol, Coll Med, Songnam 463707, South Korea
[3] Seoul Natl Univ, Bundang Hosp, Dept Pathol, Coll Med, Songnam 463707, South Korea
[4] Natl Med Ctr, Dept Otorhinolaryngol, Seoul, South Korea
[5] Seoul Natl Univ, Med Res Ctr, Sensory Organ Res Inst, Seoul, South Korea
关键词
Immunoglobulin G; Hearing loss; Autoimmune disease; IGG4;
D O I
10.3342/ceo.2011.4.1.52
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
IgG4-related systemic disease, including autoimmune pancreatitis, is a multi-organ disorder characterized by elevated serum immunoglobulin G4 (IgG4) concentration and IgG4-positive plasma cell infiltration. We report a case of a 66-years-old woman with IgG4-related hearing disorder, presenting with fluctuating mixed hearing loss with middle ear effusion. The serum IgG4 level was elevated and pathological examination revealed dense infiltration of IgG4-positive lymphocyte in the renal parenchyma, lung tissue and lacrimal gland. With intravenous methylprednisolone at a dose of 60 mg daily, improvement of hearing loss were observed. No recurrence was observed for 6 months with mainternance of prednisolone and methotrexate.
引用
收藏
页码:52 / 54
页数:3
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