Control of C-elegans larval development by neuronal expression of a TGF-beta homolog

被引：436

作者：

Ren, PF

Lim, CS

Johnsen, R

Albert, PS

Pilgrim, D

Riddle, DL

机构：

[1] UNIV MISSOURI,PROGRAM MOL BIOL,COLUMBIA,MO 65211

[2] UNIV MISSOURI,DIV BIOL SCI,COLUMBIA,MO 65211

[3] UNIV ALBERTA,DEPT BIOL SCI,EDMONTON,AB T6G 2E9,CANADA

来源：

SCIENCE | 1996年 / 274卷 / 5291期

关键词：

D O I：

10.1126/science.274.5291.1389

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Caenorhabditis elegans dauer larva is specialized for dispersal without growth and is formed under conditions of overcrowding and limited food. The daf-7 gene, required for transducing environmental cues that support continuous development with plentiful food, encodes a transforming growth factor-beta (TGF-beta) superfamily member. A daf-7 reporter construct is expressed in the ASI chemosensory neurons. Dauer-inducing pheromone inhibits daf-7 expression and promotes dauer formation, whereas food reactivates daf-7 expression and promotes recovery from the dauer state. When the food/pheromone ratio is high, the level of daf-7 mRNA peaks during the L1 larval stage, when commitment to non-dauer development is made.

引用

页码：1389 / 1391

页数：3

共 27 条

[1] CONTROL OF LARVAL DEVELOPMENT BY CHEMOSENSORY NEURONS IN CAENORHABDITIS-ELEGANS [J].