Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis

被引：11

作者：

Chen, Wei-Ping ^{[1
]}

Bao, Jia-Peng ^{[1
]}

Tang, Jin-Li ^{[1
]}

Hu, Peng-Fei ^{[1
]}

Wu, Li-Dong ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Med, Hosp 2, Dept Orthoped Surg, Hangzhou 310009, Zhejiang, Peoples R China

来源：

RHEUMATOLOGY INTERNATIONAL | 2011年 / 31卷 / 10期

关键词：

Trichostatin A; Osteoarthritis; Cystatin C; Cathepsins; ACLT; HISTONE DEACETYLASE INHIBITORS; COLLAGEN-INDUCED ARTHRITIS; ARTICULAR CHONDROCYTES; SYNOVIAL INFLAMMATION; CARTILAGE DEGRADATION; K EXPRESSION; MOUSE MODEL; IN-VIVO; CELLS; CLEAVAGE;

D O I：

10.1007/s00296-010-1481-7

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The aim of this study was to investigate the effects of trichostatin A (TSA) on expression of cathepsins in cartilage in experimental osteoarthritis (OA). OA was induced in 18 rabbits by bilateral anterior cruciate ligament transection (ACLT). Four weeks after surgery, rabbits received intra-articular injection with TSA dissolved in the dimethylsulphoxide (DMSO) in the right knees and DMSO in the left knees once a week for 5 weeks. Rabbits were killed 7 days after the last injection. The knee joints were assessed by morphological and histological examination. Messenger RNA expression of cathepsins K, B, L, S and cystatin C was studied by real-time PCR. TSA inhibited the expression of cathepsins K, B, L, S and cystatin C accompanied with the less degradation in cartilage. The results suggest that TSA exhibits protective effects against cartilage degradation in rabbits with OA and the effects may be associated with the inhibition of cathepsins.

引用

页码：1325 / 1331

页数：7

共 36 条

[1]

Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation [J].