Decreased susceptibility to azithromycin and erythromycin mediated by a novel mtr(R) promoter mutation in Neisseria gonorrhoeae

被引：52

作者：

Zarantonelli, L

Borthagaray, G

Lee, EH

Veal, W

Shafer, WM

机构：

[1] Natl Ctr Gonococcal Antimicrobial Susceptibil Sur, Dept Microbiol, Sch Chem, Montevideo 11800, Uruguay

[2] Emory Univ, Sch Med, Dept Immunol & Microbiol, Atlanta, GA 30332 USA

[3] VA Med Ctr Atlanta, Med Res Serv, Labs Microbial Pathogenesis, Decatur, GA 30333 USA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2001年 / 47卷 / 05期

关键词：

D O I：

10.1093/jac/47.5.651

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

During a screen of Neisseria gonorrhoeae clinical isolates obtained in Uruguay for susceptibility to azithromycin, we noticed that approximately 10% of the strains examined displayed decreased susceptibility to azithromycin and erythromycin due to the mtr(CDE)-encoded afflux pump system, but remained susceptible to Triton X-100, We now report that the mtr(R) promoter region of one of these isolates contains a dinucleotide insertion (TT) that mediates this resistance phenotype.

引用

页码：651 / 654

页数：4

共 7 条

[1] The MtrD protein of Neisseria gonorrhoeae is a member of the resistance/nodulation/division protein family constituting part of an efflux system [J].