Opinion - Taking our breath away: dendritic cells in the pathogenesis of asthma

被引：276

作者：

Lambrecht, BN ^{[1
]}

Hammad, H ^{[1
]}

机构：

[1] Erasmus MC, Dept Pulm Med, NL-3015 GE Rotterdam, Netherlands

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 12期

关键词：

D O I：

10.1038/nri1249

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) are mainly known for their capacity to induce primary immune responses. Here, we propose that DCs are similarly essential for controlling effector T-cell responses and, therefore, might have a role in T-cell-mediated diseases. In the case of asthma, airway DCs are essential for controlling T helper 2 (TH2)-dependent eosinophilic airway inflammation. Therefore, interfering with DC function could be of therapeutic benefit.

引用

页码：994 / 1003

页数：10

共 85 条

[1] Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
Akbari, O
DeKruyff, RH
Umetsu, DT
[J]. NATURE IMMUNOLOGY, 2001, 2 (08) : 725 - 731
[2] Akbari O, 2002, NAT MED, V8, P1024, DOI 10.1038/nm745
[3] A polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E
Baldini, M
Lohman, IC
Halonen, M
Erickson, RP
Holt, PG
Martinez, FD
[J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1999, 20 (05) : 976 - 983
[4] Dendritic cells and the control of immunity
Banchereau, J
Steinman, RM
[J]. NATURE, 1998, 392 (6673) : 245 - 252
[5] Comparison of allergen-stimulated dendritic cells from atopic and nonatopic donors dissecting their effect on autologous naive and memory T helper cells of such donors
Bellinghausen, I
Brand, U
Knop, J
Saloga, J
[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 105 (05) : 988 - 996
[6] Mucosal CD8α+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties
Bilsborough, J
George, TC
Norment, A
Viney, JL
[J]. IMMUNOLOGY, 2003, 108 (04) : 481 - 492
[7] Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein
Brimnes, MK
Bonifaz, L
Steinman, RM
Moran, TM
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (01) : 133 - 144
[8] Glucocorticoid-induced apoptosis of dendritic cells in the rat tracheal mucosa
Brokaw, JJ
White, GW
Baluk, P
Anderson, GP
Umemoto, EY
McDonald, DM
[J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1998, 19 (04) : 598 - 605
[9] Meeting Koch's postulates for calcium signaling in cardiac hypertrophy
Chien, KR
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (10) : 1339 - 1342
[10] Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ
Constant, SL
Brogdon, JL
Piggott, DA
Herrick, CA
Visintin, I
Ruddle, NH
Bottomly, K
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (10) : 1441 - 1448

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