The evolution of the antiaging action of dietary restriction: A hypothesis

被引:137
作者
Masoro, EJ
Austad, SN
机构
[1] Aging Research and Education Center, Univ. of Texas Health Science Center, San Antonio, TX
[2] Department of Biological Sciences, University of Idaho
[3] Department of Physiology, Univ. of Texas Health Science Center, San Antonio, TX 78284-7756
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 1996年 / 51卷 / 06期
关键词
D O I
10.1093/gerona/51A.6.B387
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Reducing the intake of dietary energy by laboratory rodents to wed below that of animals allowed to eat ad libitum slows the rate of aging. This phenomenon, which is robust and reproducible, if known as the antiaging action of dietary restriction (DR). We hypothesize that this DR response arose because of its evolutionary advantage with respect to survival during periods of unpredictable, short-term food shortage. In our evolutionary scenario,food shortage led to an adaptive redirection of resources away from reproduction toward somatic maintenance via an enhanced heat shock protein response in invertebrates. In vertebrates, an additional involvement of the hypothalamic-adenohypophyseal-adrenal glucocorticoid system was necessitated to protect against excessive systemic defense responses. We suggest several general implications of oar hypothesis.
引用
收藏
页码:B387 / B391
页数:5
相关论文
共 53 条
[1]   CHRONIC CALORIC RESTRICTION INDUCES STRESS PROTEINS IN THE HYPOTHALAMUS OF RATS [J].
ALY, KB ;
PIPKIN, JL ;
HINSON, WG ;
FEUERS, RJ ;
DUFFY, PH ;
LYNCOOK, L ;
HART, RW .
MECHANISMS OF AGEING AND DEVELOPMENT, 1994, 76 (01) :11-23
[2]  
[Anonymous], GENETIC EFFECTS AGIN
[3]   CHRONIC FOOD RESTRICTION AND THE CIRCADIAN-RHYTHMS OF PITUITARY-ADRENAL HORMONES, GROWTH-HORMONE AND THYROID-STIMULATING HORMONE [J].
ARMARIO, A ;
MONTERO, JL ;
JOLIN, T .
ANNALS OF NUTRITION AND METABOLISM, 1987, 31 (02) :81-87
[4]  
ASQUITH PJ, 1989, YEARB PHYS ANTHROPOL, V32, P129
[6]   LONG-TERM ACTION OF PREDNISOLONE PHOSPHATE ON A STRAIN OF SHORT-LIVED MICE [J].
BELLAMY, D .
EXPERIMENTAL GERONTOLOGY, 1968, 3 (04) :327-+
[8]   THE ROLE OF AGING IN CANCER INCIDENCE - AN EPIDEMIOLOGICAL-STUDY [J].
DIX, D .
JOURNALS OF GERONTOLOGY, 1989, 44 (06) :10-18
[9]   INFLUENCE OF FASTING ON GLYCOGEN DEPLETION IN RATS DURING EXERCISE [J].
DOHM, GL ;
TAPSCOTT, EB ;
BARAKAT, HA ;
KASPEREK, GJ .
JOURNAL OF APPLIED PHYSIOLOGY, 1983, 55 (03) :830-833
[10]  
Duffy P.H., 1995, DIETARY RESTRICTION, P125