UCL1684:: a potent blocker of Ca2+-activated K+ channels in rat adrenal chromaffin cells in culture

被引：27

作者：

Dunn, PM ^{[1
]}

机构：

[1] Univ London Univ Coll, Dept Pharmacol, London WC1E 6BT, England

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 368卷 / 01期

基金：

英国惠康基金;

关键词：

K+ channel; Ca2+-activated; apamin; chromaffin cell; UCL; 1684;

D O I：

10.1016/S0014-2999(99)00029-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The novel K+ channel blocker 6,10-diaza-3(1,3)8,(1,4)-dibenzena-1,5(1,4)-diquinolinacyclodecaphane (UCL 1684) has been tested for its ability to inhibit Ca2+-activated K+ currents in cultured rat chromaffin cells. Low nanomolar concentrations of UCL 1684 produced a rapid and reversible inhibition of the slow, apamin-sensitive, tail current activated by a depolarizing voltage command. This compound also inhibited the muscarine activated outward current with an IC50 of 6 nM. These results confirm UCL 1684 to be the most potent non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel so far described. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：119 / 123

页数：5

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