Three-dimensional conformal radiotherapy for hepatocellular carcinoma with inferior vena cava invasion

被引:19
作者
Igaki, Hiroshi [1 ]
Nakagawa, Keiichi
Shiraishi, Kenshiro
Shiina, Shuichiro [2 ]
Kokudo, Norihiro [3 ]
Terahara, Atsuro
Yamashita, Hideomi
Sasano, Nakashi
Omata, Masao [2 ]
Ohtomo, Kuni
机构
[1] Tokyo Univ Hosp, Dept Radiol, Bunkyo Ku, Tokyo 1138655, Japan
[2] Tokyo Univ Hosp, Dept Gastroenterol, Tokyo 1138655, Japan
[3] Tokyo Univ Hosp, Dept Hepato Biliary Pancreat Surg, Tokyo 1138655, Japan
关键词
hepatocellular carcinoma; inferior vena cava; three-dimensional conformal radiation therapy; hepatic functional reserve; liver cirrhosis;
D O I
10.1093/jjco/hyn038
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Hepatocellular carcinoma with inferior vena cava invasion is a rare but fatal condition of disease progression. The aim of this study was to analyze the results of treatment for hepatocellular carcinoma with inferior vena cava invasion by three-dimensional conformal radiation therapy. Methods: From 1990 to 2006, 18 histopathologically confirmed hepatocellular carcinoma patients with inferior vena cava invasion who were unsuitable for surgery were treated by three-dimensional conformal radiation therapy at our hospital with two to four static or dynamic conformal arc fields. Results: A median total tumor dose of 50 Gy (range 30-60 Gy) was delivered. The progression-free rate was 91.6% among the patients in whom follow-up computed tomography was obtained. Actuarial survival at 1 year was 33.3%, and the median survival period was 5.6 months. Conclusions: Three-dimensional conformal radiation therapy might offer a chance of long survival for a part of the hepatocellular carcinoma patients with inferior vena cava invasion, since a third of such patients survived more than a year. Additional treatments should be considered to prevent distant metastases and hepatic functional deterioration after three-dimensional conformal radiation therapy.
引用
收藏
页码:438 / 444
页数:7
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