Radiation and the microenvironment - Tumorigenesis and therapy

被引：402

作者：

Barcellos-Hoff, MH

Park, C

Wright, EG

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

[2] Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA 94143 USA

[3] Univ Dundee, Ninewells Hosp & Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 11期

关键词：

D O I：

10.1038/nrc1735

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiation rapidly and persistently alters the soluble and insoluble components of the tissue microenvironment. This affects the cell phenotype, tissue composition and the physical interactions and signalling between cells. These alterations in the microenvironment can contribute to carcinogenesis and alter the tissue response to anticancer therapy. Examples of these responses and their implications are discussed with a view to therapeutic intervention.

引用

页码：867 / 875

页数：9

共 97 条

[1] Making sense of latent TGFβ activation [J].