PlGF-MMP-9-expressing cells restore microcirculation and efficacy of cell therapy in aged dystrophic muscle

被引：102

作者：

Gargioli, Cesare ^{[1
,2
]}

Coletta, Marcello ^{[1
]}

De Grandis, Fabrizio ^{[1
,2
]}

Cannata, Stefano M. ^{[2
]}

Cossu, Giulio ^{[1
,3
,4
]}

机构：

[1] San Raffaele Biomed Pk Fdn Rome, I-10028 Rome, Italy

[2] Univ Roma Tor Vergata, Dept Biol, I-00173 Rome, Italy

[3] Ist Sci San Raffaele, Stem Cell Res Inst, I-20132 Milan, Italy

[4] Univ Milan, Dept Biol, I-20129 Milan, Italy

来源：

NATURE MEDICINE | 2008年 / 14卷 / 09期

关键词：

D O I：

10.1038/nm.1852

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sclerosis and reduced microvessel density characterize advanced stages of muscular dystrophy and hamper cell or gene delivery, precluding treatment of most individuals with Duchenne muscular dystrophy. Modified tendon fibroblasts expressing an angiogenic factor (placenta growth factor, PlGF) and a metalloproteinase (matrix metalloproteinase-9, MMP-9) are able to restore a vascular network and reduce collagen deposition, allowing efficient cell therapy in aged dystrophic mice. These data open the possibility of extending new therapies to currently untreatable individuals.

引用

页码：973 / 978

页数：6

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