Prevalence of diabetes-associated autoantibodies in schoolchildren - The Karlsburg type 1 diabetes risk study

被引：18

作者：

Schlosser, M

Strebelow, M

Rjasanowski, I

Kerner, W

Wassmuth, R

Ziegler, M

机构：

[1] Univ Greifswald, Inst Pathophysiol, D-17495 Karlsburg, Germany

[2] L A D GmbH Hennigsdorf, Branch Karlsburg, Karlsburg, Germany

[3] Ctr Diabet & Metab Disorders, Karlsburg, Germany

[4] Univ Dusseldorf, Inst Transplantat Diagnost & Cell Therapeut, D-4000 Dusseldorf, Germany

[5] Inst Diabet Gerhardt Katsch, D-2201 Karlsburg, Germany

来源：

IMMUNOLOGY OF DIABETES III | 2004年 / 1037卷

关键词：

autoantibodies; type; 1; diabetes; general population;

D O I：

10.1196/annals.1337.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study attempts to assess the prevalence of diabetes-associated autoantibodies in a general population in the northeastern part of Germany, with emphasis on autoantibodies against glutamic acid decarboxylase (GADA), protein tyrosine phosphatase (IA-2A), and insulin (IAA) by radioassays >= 98th percentile, and AAbs binding on pancreatic sections (ICA) by immunofluorescence >= 10 Juvenile Diabetes Foundation units. From a total of 11,840 schoolchildren tested for all four AAbs, 821 (6.9%) children were positive for single AAbs, whereas 83 (0.7%) had multiple AAbs. If the primary screening were performed by testing GADA/IA-2A/IAA, 94% of probands with single AAbs and all with multiple AAbs would be identified. The combinations of GADA/IA-2A, GADA/IAA, and IA-2A/IAA would identify 97.6, 98.8, and 85.5%, of probands with multiple AAbs, respectively. Thus, combined AAb screening in the general population identifies those probands at risk for diabetes.

引用

页码：114 / 117

页数：4

共 4 条

[1]

ATKINSON MA, 1994, NEW ENGL J MED, V331, P1428

[2] The Karlsburg type 1 diabetes risk study of a normal schoolchild population:: Association of β-cell autoantibodies and human leukocyte antigen-DQB1 alleles in antibody-positive individuals [J].