GDNF protects the cochlea against noise damage

被引：62

作者：

Keithley, EM

Ma, CL

Ryan, AF

Louis, JC

Magal, E

机构：

[1] Univ Calif San Diego, Sch Med, Dept Otolaryngol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA

[3] VAMC, La Jolla, CA USA

[4] Amgen Inc, Dept Neurosci, Thousand Oaks, CA 91320 USA

来源：

NEUROREPORT | 1998年 / 9卷 / 10期

关键词：

glial-derived neurotrophic factor; hair cells; inner ear; protection; rescue;

D O I：

10.1097/00001756-199807130-00007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GLIAL-DERIVED neurotrophic factor (GDNF) was tested for its ability to prevent hearing and sensory cell loss in guinea pigs exposed to acoustic trauma. Hearing was measured prior to any treatment. Animals were exposed to damaging levels of noise either before or after local application of GDNF to one ear. Four weeks later, hearing and sensory cell loss was greater in the control ear than in the ear receiving GDNF before acoustic trauma or 2 h after trauma, but not 4 or 6 h after trauma. The results indicate that GDNF treatment in vivo can prevent cochlear sensory cell damage and hearing loss if present during or shortly after acoustic trauma. Neuro Report 9: 2183-2187 (C) 1998 Rapid Science Ltd.

引用

页码：2183 / 2187

页数：5

共 23 条

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