Genetic risk factors for chronic obstructive pulmonary disease

被引：30

作者：

Sandford, AJ

Paré, PD

机构：

[1] St Pauls Hosp, Ctr Hlth Evaluat & Outcomes Sci, Vancouver, BC V6Z 1Y6, Canada

[2] Univ British Columbia, Pulm Res Lab, Vancouver, BC V5Z 1M9, Canada

[3] Univ British Columbia, Dept Med, Vancouver, BC V5Z 1M9, Canada

来源：

CLINICS IN CHEST MEDICINE | 2000年 / 21卷 / 04期

关键词：

D O I：

10.1016/S0272-5231(05)70173-8

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

There is convincing epidemiologic evidence of genetic susceptibility to chronic obstructive pulmonary disease (COPD). Identification of susceptibility genes could yield important insights into the pathogenesis of COPD and may provide targets for therapeutic intervention. Deficiency of alpha(1)-antitrypsin is the only well-established genetic risk factor for COPD, but several other genes are implicated in the pathogenesis of this disease, Genetic factors may also modify the disease phenotype without being directly involved in the pathogenesis.

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页码：633 / +

页数：12

相关论文

共 94 条

[1] GENETIC DIFFERENCES IN VENTILATORY RESPONSE TO INHALED CO2 [J].

ARKINSTALL, WW ;

NIRMEL, K ;

KLISSOURAS, V ;

MILICEMI.J .

JOURNAL OF APPLIED PHYSIOLOGY, 1974, 36 (01) :6-11

[2] Peculiarities of the GSTM1 0/0 genotype in French heavy smokers with various types of chronic bronchitis [J].

Baranova, H ;

Perriot, J ;

Albuisson, E ;

Ivaschenko, T ;

Baranov, VS ;

Hemery, B ;

Mouraire, P ;

Riol, N ;

Malet, P .

HUMAN GENETICS, 1997, 99 (06) :822-826

[3] Genetics and pulmonary medicine - 9 - Molecular genetics of chronic obstructive pulmonary disease [J].

Barnes, PJ .

THORAX, 1999, 54 (03) :245-252

[4]

BARNETT TB, 1975, AM REV RESPIR DIS, V111, P587

[5]

BECK GJ, 1981, AM REV RESPIR DIS, V123, P149

[6] α1-antitrypsin TAQ I polymorphism and α1-antichymotrypsin mutations in patients with obstructive pulmonary disease [J].

Benetazzo, MG ;

Gilè, LS ;

Bombieri, C ;

Malerba, G ;

Massobrio, M ;

Pignatti, PF ;

Luisetti, M .

RESPIRATORY MEDICINE, 1999, 93 (09) :648-654

[7] Complete mutational screening of the CFTR gene in 120 patients with pulmonary disease [J].

Bombieri, C ;

Benetazzo, M ;

Saccomani, A ;

Belpinati, F ;

Gilè, LS ;

Luisetti, M ;

Pignatti, PF .

HUMAN GENETICS, 1998, 103 (06) :718-722

[8] GENETIC AND SOCIAL INFLUENCES ON STARTING TO SMOKE - A STUDY OF DUTCH ADOLESCENT TWINS AND THEIR PARENTS [J].

BOOMSMA, DI ;

KOOPMANS, JR ;

VANDOORNEN, LJP ;

ORLEBEKE, JF .

ADDICTION, 1994, 89 (02) :219-226

[9] Secretion of tumour necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles. Relevance for inflammatory bowel disease [J].

Bouma, G ;

Crusius, JBA ;

Pool, MO ;

Kolkman, JJ ;

VonBlomberg, BME ;

Kostense, PJ ;

Giphart, MJ ;

Schreuder, GMT ;

Meuwissen, SGM ;

Pena, AS .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1996, 43 (04) :456-463

[10] CLINICAL-FEATURES AND HISTORY OF THE DESTRUCTIVE LUNG-DISEASE ASSOCIATED WITH ALPHA-1-ANTITRYPSIN DEFICIENCY OF ADULTS WITH PULMONARY SYMPTOMS [J].

BRANTLY, ML ;

PAUL, LD ;

MILLER, BH ;

FALK, RT ;

WU, M ;

CRYSTAL, RG .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 138 (02) :327-336

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