Identification of SorCS2, a novel member of the VPS10 domain containing receptor family, prominently expressed in the developing mouse brain

被引：52

作者：

Rezgaoui, M ^{[1
]}

Hermey, G ^{[1
]}

Riedel, IB ^{[1
]}

Hampe, W ^{[1
]}

Schaller, HC ^{[1
]}

Hermans-Borgmeyer, I ^{[1
]}

机构：

[1] Univ Hamburg, Zentrum Mol Neurobiol, D-20246 Hamburg, Germany

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 100卷 / 02期

关键词：

orphan receptor; central nervous system development; floor plate;

D O I：

10.1016/S0925-4773(00)00523-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report the identification of a fourth member of the VPS10 domain containing receptor family, SorCS2, highly expressed in the developing and mature murine central nervous system. During early central nervous system development its main site of expression is the floor plate. In addition, high transcript levels were detected transiently in a variety of brain regions including the dopaminergic midbrain nuclei and the dorsal thalamus. Outside the nervous system expression is detected in lung and heart and transiently in a variety of mesodermally derived tissues. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：335 / 338

页数：4

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