Clinical Study of Changes of Cerebral Microcirculation in Cerebral Vasospasm After SAH

被引：15

作者：

Chai, Wei-na ^{[1
]}

Sun, Xiao-chuan ^{[1
]}

Lv, Fa-jin ^{[2
]}

Wan, Bin ^{[2
]}

Jiang, Li ^{[1
]}

机构：

[1] Chongqing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Chongqing 400016, Peoples R China

[2] Chongqing Med Univ, Dept Radiol, Affiliated Hosp 1, Chongqing 400016, Peoples R China

来源：

EARLY BRAIN INJURY OR CEREBRAL VASOSPASM, VOL 1: PATHOPHYSIOLOGY | 2011年 / 110卷

关键词：

Cerebral microcirculation; Cerebral vasospasm; CT perfusion; Subarachnoid hemorrhage; SUBARACHNOID HEMORRHAGE;

D O I：

10.1007/978-3-7091-0353-1_39

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Aim to investigate the changes of cerebral microcirculation after subarachnoid hemorrhage (SAH) and its association with cerebral vasospasm (CVS) after SAH. CTP was performed in 85 patients with SAH and 35 controls. Cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) were recorded for final analysis. CTP parameters were compared between (1) SAH group and control group, (2) CVS group and non-CVS group (nCVS), (3) symptomatic CVS (sCVS) group and asymptomatic CVS (asCVS) group. Compared to control group, there were significant differences in CBF and MTT of SAH patients (P < 0.05). Among SAH patients, the CBF and MTT (a decreased CBF and a prolonged MTT) of CVS patients were significantly different from those of non-CVS patients (P < 0.05). In 46 CVS patients, sCVS group presented significantly lower CBF and more prolonged MTT than asCVS patients (P < 0.05). Seven cases with MTT between 6.31 and 12.72 s showed delayed ischemic neurological deficit (DIND), two of whom had hemiplegia, and one died. Our findings suggest that CTP examination contributes to uncover the changes of cerebral microcirculation after SAH, and the changes of cerebral microcirculation are associated with CVS post SAH.

引用

页码：225 / +

页数：2

共 7 条

[1]

Vasospasm probability index: a combination of transcranial Doppler velocities, cerebral blood flow, and clinical risk factors to predict cerebral vasospasm after aneurysmal subarachnoid hemorrhage [J].