Evidence for in-vivo transfer of mecA DNA between strains of Staphylococcus aureus

被引：140

作者：

Wielders, CLC ^{[1
]}

Vriens, MR ^{[1
]}

Brisse, S ^{[1
]}

de Graaf-Miltenburg, LAM ^{[1
]}

Troelstra, A ^{[1
]}

Fleer, A ^{[1
]}

Schmitz, FJ ^{[1
]}

Verhoef, J ^{[1
]}

Fluit, AC ^{[1
]}

机构：

[1] Univ Utrecht, Med Ctr, Eijkman Winkler Inst Microbiol Infect Dis & Infla, NL-3584 CX Utrecht, Netherlands

来源：

LANCET | 2001年 / 357卷 / 9269期

关键词：

D O I：

10.1016/S0140-6736(00)04832-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Staphylococcus aureus is thought to have acquired mecA DNA by horizontal transfer. DNA fingerprints made by restriction nucleases that cut certain sequences of DNA are used to compare complete genomes or particular genes between bacteria. We isolated an epidemic mecA(-) meticillin-susceptible S aureus genotype and, subsequently, a rare isogeneic mecA(+) meticillin-resistant S aureus (MRSA) genotype from a neonate who had never been in contact with MRSA. This MRSA contained mecA DNA that was identical to that in a coagulase-negative staphylococcal strain isolated from this patient, but different from other MRSA genotypes. We believe that this MRSA was formed in vivo by horizontal transfer of the mecA DNA between two staphylococcal species.

引用

页码：1674 / 1675

页数：2

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