Stimulatory effect on osseous repair of zinc-substituted hydroxyapatite: Histological study in rabbit's tibia

被引：13

作者：

Calasans-Maia, M. ^{[1
]}

Rossi, A. M. ^{[2
]}

Dias, E. P. ^{[1
]}

Santos, S. R. A. ^{[2
]}

Ascoli, F. ^{[1
]}

Granjeiro, J. M. ^{[1
]}

机构：

[1] Univ Fed Fluminense, Lab Bioengn & Biomat, Niteroi, RJ, Brazil

[2] Ctr Brasileiro Pesquisas Fis, Lab Biomat LABIOMAT MCT, Rio De Janeiro, Brazil

来源：

BIOCERAMICS, VOL 20, PTS 1 AND 2 | 2008年 / 361-363卷

关键词：

hydroxyapatite; zinc-containing hydroxyapatite; bone repair; rabbit tibia; osteoconduction; light microscopy;

D O I：

10.4028/www.scientific.net/KEM.361-363.1269

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 [材料科学与工程]; 080502 [材料学];

摘要：

The study was carried out aiming the evaluation of the effect of hydroxyapatite (HA) and zinc-substituted hydroxyapatite (ZnHA) on osseous repair of rabbit's tibia. For the study, 15 adult animals, weighing around 2.5 and 3.0 Kg, sourced by the Fluminense Federal University Animal Lab were acquired. Two perforations were created in each tibia and filled with cylinders (2x6 mm) of HA (group 1, right) or ZnHA (group 2, left). The animals were killed after 7, 14, and 28 days for evaluating the histological aspects of the interface site and bone repair. No sign of inflammatory reaction surrounding the cylinders area were observed. neither giant cells. Osteogenesis was evidently accelerated in all healing periods for the ZnHA group in regards to the HA group. Randomly dispersed areas of neoformed bone among wide areas of fibrous connective tissue was observed in the HA group. We conclude that both biomaterials are biocompatible, but zinc-containg HA enhanced and accelerated the osteogenesis in relation to HA.

引用

页码：1269 / +

页数：3

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