Cysteinyl peptide inhibitors of Bacillus cereus zinc β-lactamase

被引：56

作者：

Bounaga, S

Galleni, M

Laws, AP

Page, MI ^{[1
]}

机构：

[1] Univ Huddersfield, Dept Chem & Biol Sci, Huddersfield HD1 3DH, W Yorkshire, England

[2] Univ Liege, Ctr Ingn Prot, Inst Chim B6, B-4000 Liege 1, Belgium

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0968-0896(00)00257-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-beta -lactamase. The pH dependence of pK(i) indicates that the thiol anion displaces hydroxide ion from the active site zinc(II). D,D-Peptides bind to the enzyme better than other diastereoisomers, which is compatible with the predicted stereochemistry of the active site. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：503 / 510

页数：8

共 43 条

[1] THE AMINO-ACID SEQUENCE OF THE ZINC-REQUIRING BETA-LACTAMASE-II FROM THE BACTERIUM BACILLUS-CEREUS-569
AMBLER, RP
DANIEL, M
FLEMING, J
HERMOSO, JM
PANG, C
WALEY, SG
[J]. FEBS LETTERS, 1985, 189 (02) : 207 - 211
[2] THE PRODUCTION AND MOLECULAR-PROPERTIES OF THE ZINC BETA-LACTAMASE OF PSEUDOMONAS-MALTOPHILIA IID-1275
BICKNELL, R
EMANUEL, EL
GAGNON, J
WALEY, SG
[J]. BIOCHEMICAL JOURNAL, 1985, 229 (03) : 791 - 797
[3] BOUNAGA S, 1998, BIOCH J, V331
[4] X-ray structure of the ZnII β-Lactamase from Bacteroides fragilis in an orthorhombic crystal form
Carfi, A
Duee, E
Paul-Soto, R
Galleni, M
Frere, JM
Dideberg, O
[J]. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 1998, 54 : 47 - 57
[5] Purification, crystallization and preliminary X-ray analysis of Bacteroides fragilis Zn2+ beta-lactamase
Carfi, A
PaulSoto, R
Martin, L
Petillot, Y
Frere, JM
Dideberg, O
[J]. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 1997, 53 : 485 - 487
[6] 1.85 A resolution structure of the zincII β-lactamase from Bacillus cereus
Carfi, A
Duee, E
Galleni, M
Frere, JM
Dideberg, O
[J]. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1998, 54 : 313 - 323
[7] THE 3-D STRUCTURE OF A ZINC METALLO-BETA-LACTAMASE FROM BACILLUS-CEREUS REVEALS A NEW-TYPE OF PROTEIN FOLD
CARFI, A
PARES, S
DUEE, E
GALLENI, M
DUEZ, C
FRERE, JM
DIDEBERG, O
[J]. EMBO JOURNAL, 1995, 14 (20) : 4914 - 4921
[8] Concha NO, 1997, PROTEIN SCI, V6, P2671
[9] Crystal structure of the wide-spectrum binuclear zinc beta-lactamase from Bacteroides fragilis
Concha, NO
Rasmussen, BA
Bush, K
Herzberg, O
[J]. STRUCTURE, 1996, 4 (07) : 823 - 836
[10] Appearance of IMP-1 metallo-β-lactamase in Europe
Cornaglia, G
Riccio, ML
Mazzariol, A
Lauretti, L
Fontana, R
Rossolini, GM
[J]. LANCET, 1999, 353 (9156) : 899 - 900

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