Influence of sperm surface antibodies on spontaneous pregnancy rates

Objective: To determine the rates of spontaneous pregnancies among women whose infertile male partners had sperm surface antibodies. Design: Retrospective analysis. Setting: Infertility clinic of a university referral center. Patient(s): One hundred fifty-seven infertile couples; the male partner had IgA and/or IgG sperm surface antibody concentrations of >10%. Intervention: None. Main Outcome Measure(s): Spontaneous pregnancy rates (PRS) over 6 years. Result(s): Spontaneous PRs correlated negatively with antibody concentrations. Conclusion(s): Although the chance of spontaneous pregnancy among women whose partners had sperm antibody concentrations of <50% was good, intracytoplasmic sperm injection should be recommended to patients with concentrations of >90%. (Fertil Steril(R) 1998;70:355-6. (C) 1998 by American Society for Reproductive Medicine.).