Estrogen and bone -: a reproductive and locomotive perspective

被引：106

作者：

Järvinen, TL

Kannus, P

Sievänen, H

机构：

[1] Univ Tampere, Sch Med, Tampere, Finland

[2] Univ Tampere, Inst Med Technol, Tampere, Finland

[3] Tampere Univ Hosp, Dept Surg, Tampere, Finland

[4] Bone Res Grp, UKK Inst, Tampere, Finland

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2003年 / 18卷 / 11期

关键词：

menopause; osteoporosis; mechanical loading; growth and development; estrogens;

D O I：

10.1359/jbmr.2003.18.11.1921

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The primary function of the skeleton is locomotion, and the primary function of estrogen is reproduction. When the skeleton is considered within this locomotive context, the onset of estrogen secretion at puberty leads to packing of mechanically excess mineral into female bones for reproductive needs. Accordingly, the unpacking of this reproductive safety deposit at menopause denotes the origin of type I osteoporosis.

引用

收藏

页码：1921 / 1931

页数：11

相关论文

共 110 条

[1] Postmenopausal osteoporosis - Its clinical features [J].

Albright, F ;

Smith, PH ;

Richardson, AM .

JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1941, 116 :2465-2474

[2]

ALBRIGHT FULLER, 1940, TRANS ASSOC AMER PHYSICIANS, V55, P298

[3]

[Anonymous], 1994, Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO study group

[4]

BARON R, 1986, AM J PATHOL, V122, P363

[5] Estrogens and postmenopausal osteoporosis: Was albright right after all? [J].

Bilezikian, JP .

JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (05) :774-776

[6] Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency [J].

Bilezikian, JP ;

Morishima, A ;

Bell, J ;

Grumbach, MM .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (09) :599-603

[7] The role of estrogens in male skeletal development [J].

Bilezikian, JP .

REPRODUCTION FERTILITY AND DEVELOPMENT, 2001, 13 (04) :253-259

[8] Inaccuracies inherent in dual-energy X-ray absorptiometry in vivo bone mineral density can seriously mislead diagnostic/prognostic interpretations of patient-specific bone fragility [J].

Bolotin, HH ;

Sievänen, H .

JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (05) :799-805

[9] Greatly increased cancellous bone formation with rapid improvements in bone structure in the rat maternal skeleton after lactation [J].

Bowman, BM ;

Siska, CC ;

Miller, SC .

JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (11) :1954-1960

[10] Skeletal mass, chemistry, and growth during and after multiple reproductive cycles in the rat [J].

Bowman, BM ;

Miller, SC .

BONE, 1999, 25 (05) :553-559

← 1 2 3 4 5 6 7 8 9 10 →