Significance of non-presynaptic SPECT tracer methods in Parkinson's disease

被引：13

作者：

Leenders, KL ^{[1
]}

机构：

[1] Univ Groningen Hosp, Dept Neurol, NL-9700 RB Groningen, Netherlands

来源：

MOVEMENT DISORDERS | 2003年 / 18卷

关键词：

SPECT; PET; Parkinson's disease; IBZM; HMPAO;

D O I：

10.1002/mds.10577

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tropane-related tracers for SPECT and PET scanning have shown their value in assessing the in vivo striatal presynaptic status of the dopaminergic neurotransmitter system in man. Previously. there were a few other tracers suggested to be useful in the study of in vivo brain biochemistry in humans, particularly in patients afflicted with Parkinson's disease (PD) or parkinsonian syndromes. We summarize the work concerning the two main tracers applied in that context using single photon emission tomography (SPECT) scanning in patients with PD: IBZM and HMPAO. IBZM binds specifically to striatal dopamine D-2 receptors and HMPAO uptake is a measure of cerebral tissue perfusion. (C) 2003 Movement Disorder Society.

引用

页码：S39 / S42

页数：4

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