Hepatitis C and non-Hodgkin lymphoma among 4784 cases and 6269 controls from the international lymphoma epidemiology consortium

被引：268

作者：

De Sanjose, Silvia ^{[1
]}

Benavente, Yolanda ^{[1
]}

Vajdic, Claire M. ^{[2
]}

Engels, Eric A. ^{[3
]}

Morton, Lindsay M. ^{[3
]}

Bracci, Paige M. ^{[4
]}

Spinelli, John J. ^{[5
]}

Zheng, Tongzhang ^{[6
]}

Zhang, Yawei ^{[6
]}

Franceschi, Silvia ^{[7
]}

Talamini, Renato ^{[8
]}

Holly, Elizabeth A. ^{[4
]}

Grulich, Andrew E. ^{[2
]}

Cerhan, James R. ^{[9
]}

Hartge, Patricia ^{[3
]}

Cozen, Wendy ^{[10
]}

Boffetta, Paolo ^{[7
]}

Brennan, Paul ^{[7
]}

Maynadie, Marc ^{[11
]}

Cocco, Pierluigi ^{[12
]}

Bosch, Ramon ^{[13
]}

Foretova, Lenka ^{[14
]}

Staines, Anthony ^{[15
]}

Becker, Nikolaus ^{[16
]}

Nieters, Alexandra ^{[16
]}

机构：

[1] Hosp Llobregat, Ctr Invest Biomed Red Epidemiol & Salud Publ, Inst Invest Biomed Bellvitge, Catalan Inst Oncol,Unit Ingect & Canc, Barcelona 08907, Spain

[2] Univ New S Wales, Natl Ctr HIV Epidemiol & Clin Res, Sydney, NSW, Australia

[3] NCI, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA

[4] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[5] British Columbia Canc Agcy, Canc Control Res Program, Vancouver, BC V5Z 4E6, Canada

[6] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA

[7] Int Agcy Res Canc, Genet Epidemiol Grp, F-69372 Lyon, France

[8] Aviano Canc Ctr, Epidemiol & Biostat Unit, I-33081 Aviano, Italy

[9] Mayo Clin, Coll Med, Dept Hlth Sci Res, Rochester, MN USA

[10] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[11] Fac Med Dijon, Registre Hemopathies Malignes Cote Or, Dijon, France

[12] Univ Cagliari, Dept Publ Hlth, Occupat Hlth Sect, Cagliari, Italy

[13] Hosp Tortosa Verge de la Cinta, Dept Pathol, Tortosa, Spain

[14] Masaryk Mem Canc Inst, Brno, Czech Republic

[15] Publ Hlth Univ Coll, Dept Publ Hlth, Dublin, Ireland

[16] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

来源：

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | 2008年 / 6卷 / 04期

关键词：

D O I：

10.1016/j.cgh.2008.02.011

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background & Aims: increasing evidence points towards a role of hepatitis C virus (HCV) infection in causing malignant lymphomas. We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin's lymphoma (NHL) subtypes after HCV infection. Methods: The analysis included 7 member studies from the International Lymphoma Epidemiology Consortium (InterLymph) based in Europe, North America, and Australia. Adult cases of NHL (n = 4784) were diagnosed between 1988 and 2004 and controls (n = 6269) were matched by age, sex, and study center. All studies used third-generation enzyme-linked immunosorbent assays to test for antibodies against HCV in serum samples. Participants who were human immunodeficiency virus positive or were organ-transplant recipients were excluded. Results: HCV infection was detected in 172 NHL cases (3.60%) and in 169 (2.70%) controls (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.40 -2.25). In subtype-specific analyses, HCV prevalence was associated with marginal zone lymphoma (OR, 2.47; 95% CI, 1.44-4.23), diffuse large B-cell lymphoma (OR, 2.24; 95% CI, 1.682.99), and lymphoplasmacytic lymphoma (OR, 2.57; 95% CI, 1.14-5.79). Notably, risk estimates were not increased for follicular lymphoma (OR, 1.02; 95% CI, 0.65-1.60). Conclusions: These results confirm the association between HCV infection and NHL and specific B-NHL subtypes (diffuse large B-cell lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma).

引用

页码：451 / 458

页数：8

共 54 条

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