The endocrine and reproductive function of the female Yucheng adolescents prenatally exposed to PCBs/PCDFs

被引:53
作者
Yang, CY
Yu, ML
Guo, HR
Lai, TJ
Hsu, CC
Lambert, G
Guo, YLL
机构
[1] Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth, Tainan 70428, Taiwan
[2] Chung Shan Med Coll, Dept Psychiat, Taichung, Taiwan
[3] Tainan Municipal Hosp, Dept Psychiat, Tainan, Taiwan
[4] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Child & Reprod Environm Hlth, Environm & Occupat Hlth Serv Inst,Dept Pediat, New Brunswick, NJ 08903 USA
[5] Natl Cheng Kung Univ, Coll Med, Dept Internal Med, Tainan 70428, Taiwan
关键词
PCBs; PCDF; FSH; estradiol; menstruation;
D O I
10.1016/j.chemosphere.2005.02.089
中图分类号
X [环境科学、安全科学];
学科分类号
08 [工学]; 0830 [环境科学与工程];
摘要
Background: Polychlorinated biphenyls (PCBs) and related compounds such as polychlorinated dibenzofurans (PCDFs) and polychlorinated dibenzo-dioxins (PCDDs) alter sexual maturation and endocrine function in animals. In 1978-1979, a mass poisoning occurred in central Taiwan from cooking oil contaminated by heat-degraded PCBs and oxidated compounds PCDFs. We tested the hypothesis that in utero exposed to PCBs/PCDFs alter sexual maturation, endocrine, and reproductive function in the human pubescent females. Methods: In 1997-1999, girls aged 13-19 years, born to mothers exposed to PCBs/PCDFs, was invited to participate in the study. Menstruation characteristic was recorded daily for 84 days and serum levels of estradiol, LH, FSH, and testosterone were measured on the 3rd day of menstruation. Results: A total of 17 exposed girls and controls participated, the exposed girls reported shorter mean duration of bleeding per cycle than 16 unexposed (5.5 vs 6.5 days, P = 0.0055). There was a higher rate of irregular menstrual cycle in the exposed girls(40% vs 0%, P = 0.018). Serum levels of estradiol (P = 0.016) and FSH (P = 0.061) were higher in exposed girls as compared to controls. Conclusions: We conclude that prenatal exposure to PCBs/PCDFs resulted in abnormal menstruation and higher estradiol and FSH levels in follicular phase of menstrual cycle in adolescent girls. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:355 / 360
页数:6
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