Use of the chemical structure of peptides as the starting point to design nonpeptide agonists and antagonists at peptide receptors: Examples with cholecystokinin and tachykinins

被引：23

作者：

Horwell, DC ^{[1
]}

机构：

[1] PARKE DAVIS NEUROSCI RES CTR,CAMBRIDGE CB2 2QB,ENGLAND

来源：

关键词：

CCK-B ANTAGONISTS; SELECTIVE ANTAGONISTS; RATIONAL DESIGN; GASTRIN; LIBRARY; RAT;

D O I：

10.1016/0968-0896(95)00190-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：1573 / 1576

页数：4

共 24 条

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[2] THE DEVELOPMENT OF A NOVEL SERIES OF NONPEPTIDE TACHYKININ NK3 RECEPTOR-SELECTIVE ANTAGONISTS
BODEN, P
EDEN, JM
HODGSON, J
HORWELL, DC
PRITCHARD, MC
RAPHY, J
SUMANCHAUHAN, N
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (16) : 1773 - 1778
[3] CHOLECYSTOKININ DIPEPTOID ANTAGONISTS - DESIGN, SYNTHESIS, AND ANXIOLYTIC PROFILE OF SOME NOVEL CCK-A AND CCK-B SELECTIVE AND MIXED CCK-A CCK-B ANTAGONISTS
BODEN, PR
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HILL, DR
HORWELL, DC
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[6] CHOLECYSTOKININ ANTAGONISTS - A TOXICOLOGIC PERSPECTIVE
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[J]. DRUG METABOLISM REVIEWS, 1992, 24 (02) : 267 - 293
[7] DEZUBE M, 1995, J MED CHEM, V38, P3784
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