The DNA damage response and cancer therapy

被引：1377

作者：

Lord, Christopher J. ^{[1
]}

Ashworth, Alan ^{[1
]}

机构：

[1] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

来源：

NATURE | 2012年 / 481卷 / 7381期

基金：

英国惠康基金;

关键词：

POLY(ADP-RIBOSE) POLYMERASE; HOMOLOGOUS RECOMBINATION; SYNTHETIC LETHALITY; PARP INHIBITORS; EXCISION-REPAIR; BREAST-CANCER; MUTANT-CELLS; TUMOR-CELLS; MUTATIONS; RESISTANCE;

D O I：

10.1038/nature10760

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Genomic instability is one of the most pervasive characteristics of tumour cells and is probably the combined effect of DNA damage, tumour-specific DNA repair defects, and a failure to stop or stall the cell cycle before the damaged DNA is passed on to daughter cells. Although these processes drive genomic instability and ultimately the disease process, they also provide therapeutic opportunities. A better understanding of the cellular response to DNA damage will not only inform our knowledge of cancer development but also help to refine the classification as well as the treatment of the disease.

引用

页码：287 / 294

页数：8

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