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Transcriptome analysis reveals a role of interferon-γ in human neointima formation

被引：74
作者：
Zohlnhöfer, D
Richter, T
Neumann, FJ
Nührenberg, T
Wessely, R
Brandl, R
Murr, A
Klein, CA
Baeuerle, PA
机构：
[1] Tech Univ Munich, Med Klin 1, D-80636 Munich, Germany
[2] Tech Univ Munich, Inst Pathol, D-80636 Munich, Germany
[3] Tech Univ Munich, Abt Gefasschirurg, D-80636 Munich, Germany
[4] Micromet AG, D-82152 Martinsried, Germany
[5] Univ Munich, Inst Immunol, D-80336 Munich, Germany
来源：
MOLECULAR CELL | 2001年 / 7卷 / 05期
关键词：
D O I：
10.1016/S1097-2765(01)00239-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The most effective immediate cure for coronary stenosis is stent-supported angioplasty. Restenosis due to neointima proliferation represents a major limitation. We investigated the expression of 2435 genes in atherectomy specimens and blood cells of patients with restenosis, normal coronary artery specimens, and cultured human smooth muscle cells (SMCs). Of the 223 differentially expressed genes, 37 genes indicated activation of interferon-gamma (IFN-gamma) signaling in neointimal SMCs. In cultured SMCs, lFN-gamma inhibited apoptosis. Genetic disruption of IFN-gamma signaling in a mouse model of restenosis significantly reduced the vascular proliferative response. Our data suggest an important role of lFN-gamma in the control of neointima proliferation.
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收藏
页码：1059 / 1069
页数：11
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