TMC-205 a new transcriptional up-regulator of SV40 promoter produced by an unidentified fungus - Fermentation, isolation, physico-chemical properties, structure determination and biological activities

被引：13

作者：

Sakurai, M ^{[1
]}

Kohno, J ^{[1
]}

Nishio, M ^{[1
]}

Yamamoto, K ^{[1
]}

Okuda, T ^{[1
]}

Kawano, K ^{[1
]}

Nakanishi, N ^{[1
]}

机构：

[1] Tanabe Seiyaku Co Ltd, Discovery Res Lab, Toda, Saitama 3358505, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2001年 / 54卷 / 08期

关键词：

D O I：

10.7164/antibiotics.54.628

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new transcriptional up-regulator designated TMC-205 was discovered from the fermentation broth of an unidentified fungal strain TC 1630 by using an SV40 promoter-luciferase reporter assay. Based on spectroscopic analyses, its structure was determined to be (E)-6-(3-methyl-1,3-butadienyl)-1H-indole-3-carboxylic acid. Expression of the luciferase activity was activated ca. 2-, 4-, and 6-fold by 1, 10, and 100 muM TMC-205, respectively. TMC-205 activated the transcriptional activity in a manner dependent on the presence of the enhancer element of SV40 in its promoter region.

引用

页码：628 / 634

页数：7

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