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Mechanisms of viral membrane fusion and its inhibition

被引：1094
作者：
Eckert, DM [1 ]
Kim, PS [1 ]
机构：
[1] MIT, Dept Biol, Whitehead Inst Biomed Res, Howard Hughes Med Inst, Cambridge, MA 02142 USA
来源：
ANNUAL REVIEW OF BIOCHEMISTRY | 2001年 / 70卷
关键词：
viral entry; influenza hemagglutinin; HIV-1; gp41; trimer-of-hairpins; spring loaded; prehairpin intermediate;
D O I：
10.1146/annurev.biochem.70.1.777
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Viral envelope glycoproteins promote viral infection by mediating the fusion of the viral membrane with the host-cell membrane. Structural and biochemical studies of two viral glycoproteins, influenza hemagglutinin and HIV-1 envelope protein, have led to a common model for viral entry. The fusion mechanism involves a transient conformational species that can be targeted by therapeutic strategies. This mechanism of infectivity is likely utilized by a wide variety of enveloped viruses for which similar therapeutic interventions should be possible.
引用
收藏
页码：777 / 810
页数：34
相关论文
共 199 条
  • [1] CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1
    Alkhatib, G
    Combadiere, C
    Broder, CC
    Feng, Y
    Kennedy, PE
    Murphy, PM
    Berger, EA
    [J]. SCIENCE, 1996, 272 (5270) : 1955 - 1958
  • [2] EXPRESSION AND CHARACTERIZATION OF CD4-IGG(2), A NOVEL HETEROTETRAMER THAT NEUTRALIZES PRIMARY HIV TYPE-1 ISOLATES
    ALLAWAY, GP
    DAVISBRUNO, KL
    BEAUDRY, GA
    GARCIA, EB
    WONG, EL
    RYDER, AM
    HASEL, KW
    GAUDUIN, MC
    KOUP, RA
    MCDOUGAL, JS
    MADDON, PJ
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1995, 11 (05) : 533 - 539
  • [3] HIV blocked by chemokine antagonist
    ArenzanaSeisdedos, F
    Virelizier, JL
    Rousset, D
    ClarkLewis, I
    Loetscher, P
    Moser, B
    Baggiolini, M
    [J]. NATURE, 1996, 383 (6599) : 400 - 400
  • [4] A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity
    Baba, M
    Nishimura, O
    Kanzaki, N
    Okamoto, M
    Sawada, H
    Iizawa, Y
    Shiraishi, M
    Aramaki, Y
    Okonogi, K
    Ogawa, Y
    Meguro, K
    Fujino, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (10) : 5698 - 5703
  • [5] Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection
    Baba, TW
    Liska, V
    Hofmann-Lehmann, R
    Vlasak, J
    Xu, WD
    Ayehunie, S
    Cavacini, LA
    Posner, MR
    Katinger, H
    Stiegler, G
    Bernacky, BJ
    Rizvi, TA
    Schmidt, R
    Hill, LR
    Keeling, ME
    Lu, YC
    Wright, JE
    Chou, TC
    Ruprecht, RM
    [J]. NATURE MEDICINE, 2000, 6 (02) : 200 - 206
  • [6] Structural basis for paramyxovirus-mediated membrane fusion
    Baker, KA
    Dutch, RE
    Lamb, RA
    Jardetzky, TS
    [J]. MOLECULAR CELL, 1999, 3 (03) : 309 - 319
  • [7] Membrane fusion mediated by coiled coils: A hypothesis
    Bentz, J
    [J]. BIOPHYSICAL JOURNAL, 2000, 78 (02) : 886 - 900
  • [8] Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
    Berger, EA
    Murphy, PM
    Farber, JM
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 657 - 700
  • [9] A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits is an antigenic mimic of the trimeric virion-associated structure
    Binley, JM
    Sanders, RW
    Clas, B
    Schuelke, N
    Master, A
    Guo, Y
    Kajumo, F
    Anselma, DJ
    Maddon, PJ
    Olson, WC
    Moore, JP
    [J]. JOURNAL OF VIROLOGY, 2000, 74 (02) : 627 - 643
  • [10] TRIMERIC SUBDOMAIN OF THE SIMIAN IMMUNODEFICIENCY VIRUS GLYCOPROTEIN
    BLACKLOW, SC
    LU, M
    KIM, P
    [J]. BIOCHEMISTRY, 1995, 34 (46) : 14955 - 14962
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