Cyclization of free radicals at the C-7 position of ethyl indole-2-carboxylate derivatives: an entry to a new class of duocarmycin analogues

被引：9

作者：

Al-Said, NH ^{[1
]}

Shawakfeh, KQ ^{[1
]}

Abdullah, WN ^{[1
]}

机构：

[1] Jordan Univ Sci & Technol, Dept Appl Chem Sci, Irbid 22110, Jordan

来源：

MOLECULES | 2005年 / 10卷 / 12期

关键词：

duocarmycin; free-radicals; intramolecular cyclization; indole; pyrroloquinoline;

D O I：

10.3390/10121446

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2carboxylate derivatives, through the less favorable 6-endo-trig cyclization mode.

引用

页码：1446 / 1457

页数：12

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