Growth factors controlling imaginal disc growth in Drosophila

被引:20
作者
Bryant, PJ [1 ]
机构
[1] Univ Calif Irvine, Ctr Dev Biol, Irvine, CA 92697 USA
来源
CELL CYCLE AND DEVELOPMENT | 2001年 / 237卷
关键词
D O I
10.1002/0470846666.ch14
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In the imaginal discs of Drosophila, contact-dependent cell interactions are important both for promoting cell proliferation and for limiting it at the end of the growth period. However, recent work indicates that diffusible growth factors are also important in regulating growth and proliferation. We have identified a family of five imaginal disc growth factors (IDGFs) by purifying mitogenic proteins that accumulate in conditioned medium during culture of imaginal disc cell lines, These proteins cooperate with insulin to stimulate not only proliferation, but also polarization and motility of imaginal disc cells. They are produced by the fat body and are probably active on a variety of peripheral tissues, The IDGFs are structurally related to chitinases, but they show an amino acid substitution that is known to abrogate catalytic activity and to transform chitinases into lectins, We suggest that these proteins act as endogenous mitogenic lectins and mediate nutritional effects on tissue growth, possibly by interacting with the insulin receptor pathway. Glycoproteins similar to the IDGFs are found in mammals and may constitute a novel class of growth factors and/or inflammatory cytokines.
引用
收藏
页码:182 / 199
页数:18
相关论文
共 62 条
[1]   Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4 [J].
Böhni, R ;
Riesgo-Escovar, J ;
Oldham, S ;
Brogiolo, W ;
Stocker, H ;
Andruss, BF ;
Beckingham, K ;
Hafen, E .
CELL, 1999, 97 (07) :865-875
[2]  
Britton JS, 1998, DEVELOPMENT, V125, P2149
[3]   INTRINSIC AND EXTRINSIC CONTROL OF GROWTH IN DEVELOPING ORGANS [J].
BRYANT, PJ ;
SIMPSON, P .
QUARTERLY REVIEW OF BIOLOGY, 1984, 59 (04) :387-415
[5]  
BRYANT PJ, 1990, J CELL SCI, P169
[6]   Molecular cloning and characterization of an estrogen-dependent porcine oviductal secretory glycoprotein [J].
Buhi, WC ;
Alvarez, IM ;
Choi, I ;
Cleaver, BD ;
Simmen, FA .
BIOLOGY OF REPRODUCTION, 1996, 55 (06) :1305-1314
[7]  
Burke R, 1996, DEVELOPMENT, V122, P2261
[8]  
Cai GP, 1997, J CELL BIOCHEM, V67, P257, DOI 10.1002/(SICI)1097-4644(19971101)67:2<257::AID-JCB11>3.0.CO
[9]  
2-C
[10]   The Drosophila insulin receptor is required for normal growth [J].
Chen, C ;
Jack, J ;
Garofalo, RS .
ENDOCRINOLOGY, 1996, 137 (03) :846-856