The murine nuclear orphan receptor GCNF is expressed in the XY body of primary spermatocytes

被引：32

作者：

Bauer, UM

Schneider-Hirsch, S

Reinhardt, S

Benavente, R

Maelicke, A

机构：

[1] Univ Mainz, Sch Med, Inst Physiol Chem & Pathobiochem, Mol Microbiol Lab, D-55099 Mainz, Germany

[2] Univ Wurzburg, Theodor Boveri Inst, Bioctr, Dept Cell & Dev Biol, D-97074 Wurzburg, Germany

来源：

FEBS LETTERS | 1998年 / 439卷 / 03期

关键词：

germ cell nuclear factor; neuronal cell nuclear factor; retinoid receptor-related testis-associated receptor; nuclear orphan receptor; spermatogenesis; XY body;

D O I：

10.1016/S0014-5793(98)01327-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have studied the expression of the nuclear orphan receptor GCNF (germ cell nuclear factor) on the mRNA and protein level in pubertal and adult mouse testes. We show by Northern and Western blot analyses and by in situ hybridization that GCNF is expressed in spermatocytes and round spermatids of adult mouse testis suggesting that GCNF may be a transcriptional regulator of spermatogenesis, Since the GCNF protein is accumulated in the XY body of late pachytene spermatocytes. it may be involved in transcriptional inactivation of sea chromosomes. (C) 1998 Federation of European Biochemical Societies.

引用

页码：208 / 214

页数：7

共 51 条

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