Fragile site and interstitial telomere repeat sequences at the fusion point of a de novo (Y;13) translocation

被引:26
作者
Boutouil, M
Fetni, R
Qu, JH
Dallaire, L
Richer, CL
Lemieux, N
机构
[1] UNIV MONTREAL,FAC MED,DEPT PATHOL,MONTREAL,PQ H3C 3J7,CANADA
[2] UNIV MONTREAL,FAC MED,DEPT ANAT,MONTREAL,PQ H3C 3J7,CANADA
[3] HOP ST JUSTINE,GEN MED SERV,DEPT PATHOL,MONTREAL,PQ H3T 1C5,CANADA
关键词
D O I
10.1007/s004390050216
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We describe a novel fragile site in a rearranged chromosome, associated with the presence of telomeric repeat sequences at the fusion point of a translocation between chromosomes 13 and Y. The case reported in this study shows a de novo (Y;13) translocation, which appears to represent fusion of an apparently intact chromosome Y with a chromosome 13 that has lost only part of its short arm. Ten percent of the cells show a normal karyotype without the (Y;13) translocation. Molecular cytogenetic studies of the derived Y;13 chromosome revealed three hybridization sites of the telomeric probes - one at each end and one at the breakpoint junction. A fragile site is also observed in the intrachromosomic telomeric region. This coincidence suggests that the telomere repeat sequences (TTAGGG)n, when present at an interstitial chromosomal location, can promote the formation of a novel fragile site.
引用
收藏
页码:323 / 327
页数:5
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