Alpha-synuclein haplotypes implicated in risk of Parkinson's disease

被引：63

作者：

Tan, EK

Chai, A

Teo, YY

Zhao, Y

Tan, C

Shen, H

Chandran, VR

Teoh, ML

Yih, Y

Pavanni, R

Wong, MC

Puvan, K

Lo, YL

Yap, E

机构：

[1] Singapore Gen Hosp, Dept Neurol, Singapore 169608, Singapore

[2] Singapore Gen Hosp, Dept Clin Res, Singapore 169608, Singapore

[3] Singapore Gen Hosp, Dept Hlth Screening, Singapore 169608, Singapore

[4] Natl Inst Neurosci, Singapore, Singapore

[5] SingHlth Res, Singapore, Singapore

[6] Def Med Res Inst, Singapore, Singapore

来源：

NEUROLOGY | 2004年 / 62卷 / 01期

关键词：

D O I：

10.1212/01.WNL.0000101721.25345.DC

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors examined four- and six-loci haplotype constructs (from five single nucleotide polymorphisms and three microsatellite regions) of the alpha-synuclein gene in patients with Parkinson's disease (PD) and controls in an ethnic Chinese population. Logistic regression analysis demonstrated an association of NACP-Rep1 (p = 0.002) and L478 (p < 0.0001) with risk of PD after correction for the effects of age, sex, and the other polymorphic loci. Specific four- loci and six-loci haplotypes were significantly associated with an increased or decreased risk of PD.

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页码：128 / 131

页数：4

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