Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders

被引：268

作者：

Doyle, Karen M. ^{[2
]}

Kennedy, Donna ^{[1
,3
]}

Gorman, Adrienne M. ^{[1
,3
]}

Gupta, Sanjeev ^{[2
,3
]}

Healy, Sandra J. M. ^{[1
,3
]}

Samali, Afshin ^{[1
,2
]}

机构：

[1] NUI Galway, Sch Nat Sci, Galway, Ireland

[2] NUI Galway, Sch Med, Galway, Ireland

[3] NUI Galway, Apoptosis Res Ctr, Galway, Ireland

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2011年 / 15卷 / 10期

基金：

爱尔兰科学基金会;

关键词：

neurodegeneration; ER stress; UPR; apoptosis; autophagy; Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis; prions disease; AMYOTROPHIC-LATERAL-SCLEROSIS; UBIQUITIN-PROTEASOME SYSTEM; MOTOR-NEURON DISEASE; INDUCED CELL-DEATH; ALZHEIMERS-DISEASE; ER STRESS; PARKINSONS-DISEASE; PRION PROTEIN; OXIDATIVE STRESS; ALPHA-SYNUCLEIN;

D O I：

10.1111/j.1582-4934.2011.01374.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The stimuli for neuronal cell death in neurodegenerative disorders are multi-factorial and may include genetic predisposition, environmental factors, cellular stressors such as oxidative stress and free radical production, bioenergy failure, glutamate-induced excitotoxicity, neuroinflammation, disruption of Ca2+-regulating systems, mitochondrial dysfunction and misfolded protein accumulation. Cellular stress disrupts functioning of the endoplasmic reticulum (ER), a critical organelle for protein quality control, leading to induction of the unfolded protein response (UPR). ER stress may contribute to neurodegeneration in a range of neurodegenerative disorders. This review summarizes the molecular events occurring during ER stress and the unfolded protein response and it specifically evaluates the evidence suggesting the ER stress response plays a role in neurodegenerative disorders.

引用

页码：2025 / 2039

页数：15

共 121 条

[1]

The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs [J].