Frequency of CD45RO+ subset in CD4+CD25high regulatory T cells associated with progression of hepatocellular carcinoma

被引：40

作者：

Takata, Yoshiko ^{[1
]}

Nakamoto, Yasunari ^{[1
]}

Nakada, Akiko ^{[2
]}

Terashima, Takeshi ^{[1
]}

Arihara, Fumitaka ^{[1
]}

Kitahara, Masaaki ^{[1
]}

Kakinoki, Kaheita ^{[1
]}

Arai, Kuniaki ^{[1
]}

Yamashita, Taro ^{[1
]}

Sakai, Yoshio ^{[1
]}

Yamashita, Tatsuya ^{[1
]}

Mizukoshi, Eishiro ^{[1
]}

Kaneko, Shuichi ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Med, Kanazawa, Ishikawa 9208641, Japan

[2] Otsuka Pharmaceut Co Ltd, Minato Ku, Tokyo 1088242, Japan

来源：

CANCER LETTERS | 2011年 / 307卷 / 02期

关键词：

Regulatory T cell; Dendritic cell; Hepatocellular carcinoma; CD45RO; Intracellular cytokine; DENDRITIC CELLS; PERIPHERAL-BLOOD; INCREASED POPULATIONS; FOXP3(+); DISEASE; LYMPHOCYTES; CIRCULATION; INCREASE; HEAD; GITR;

D O I：

10.1016/j.canlet.2011.03.029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The purpose of this study was to assess the properties of CD4(+)CD25(high/low/negative) T cell subsets and analyze their relation with dendritic cells (DCs) in patients with hepatocellular carcinoma (HCC). In HCC patients, the prevalence of CD45RO(+) cells in CD4(+)CD25(high) T cells was increased and associated with higher frequencies of plasmacytoid DCs. Larger proportions of this T cell subset were detected in the patients with larger tumor burdens. These results suggest that increased frequencies of the CD45RO(+) subset in CD4(+)CD25(high) Tregs in HCC patients may establish the immunosuppressive environment cooperatively with tolerogenic plasmacytoid DCs to promote disease progression of liver cancer. (C) 2011 Published by Elsevier Ireland Ltd.

引用

页码：165 / 173

页数：9

共 38 条

[1]

Dendritic cells partially abrogate the regulatory activity of CD4+CD25+ T cells present in the human peripheral blood [J].

Ahn, Justin S. ;

Krishnadas, Deepa K. ;

Agrawal, Babita .

INTERNATIONAL IMMUNOLOGY, 2007, 19 (03) :227-237

[2]

Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells [J].

Bayry, Jagadeesh ;

Triebel, Frederic ;

Kaveri, Srini V. ;

Tough, David F. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (07) :4184-4193

[3]

Regulatory T cells and inhibitory cytokines in autoimmunity [J].

Bettini, Maria ;

Vignali, Dario A. A. .

CURRENT OPINION IN IMMUNOLOGY, 2009, 21 (06) :612-618

[4]

Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4+CD25+GITR+Foxp3+CD62L+functional regulatory T-cells in patients with graft-versus-host disease [J].

Biagi, Ettore ;

Di Biaso, Iolanda ;

Leoni, Veronica ;

Gaipa, Giuseppe ;

Rossi, Vincenzo ;

Bugarin, Cristina ;

Renoldi, Giuliano ;

Parma, Matteo ;

Balduzzi, Adriana ;

Perseghin, Paolo ;

Biondi, Andrea .

TRANSPLANTATION, 2007, 84 (01) :31-39

[5]

Characterization of Circulating Dendritic Cells in Melanoma: Role of CCR6 in Plasmacytoid Dendritic Cell Recruitment to the Tumor [J].

Charles, Julie ;

Di Domizio, Jeremy ;

Salameire, Dimitri ;

Bendriss-Vermare, Nathalie ;

Aspord, Caroline ;

Muhammad, Ramzan ;

Lefebvre, Christine ;

Plumas, Joel ;

Leccia, Marie-Therese ;

Chaperot, Laurence .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 (06) :1646-1656

[6]

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival [J].

Curiel, TJ ;

Coukos, G ;

Zou, LH ;

Alvarez, X ;

Cheng, P ;

Mottram, P ;

Evdemon-Hogan, M ;

Conejo-Garcia, JR ;

Zhang, L ;

Burow, M ;

Zhu, Y ;

Wei, S ;

Kryczek, I ;

Daniel, B ;

Gordon, A ;

Myers, L ;

Lackner, A ;

Disis, ML ;

Knutson, KL ;

Chen, LP ;

Zou, WP .

NATURE MEDICINE, 2004, 10 (09) :942-949

[7]

Human Dendritic Cells Produce TGF-β1 under the Influence of Lung Carcinoma Cells and Prime the Differentiation of CD4+CD25+Foxp3+ Regulatory T Cells [J].

Dumitriu, Ingrid E. ;

Dunbar, Donald R. ;

Howie, Sarah E. ;

Sethi, Tariq ;

Gregory, Christopher D. .

JOURNAL OF IMMUNOLOGY, 2009, 182 (05) :2795-2807

[8]

Mechanisms of Disease: the evolving understanding of liver allograft rejection [J].

Eksteen, Bertus ;

Neuberger, James M. .

NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY, 2008, 5 (04) :209-219

[9]

Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells (Reprinted from vol 4, pg 330-336, 2003) [J].

Fontenot, Jason D. ;

Gavin, Marc A. ;

Rudensky, Alexander Y. .

JOURNAL OF IMMUNOLOGY, 2017, 198 (03) :986-992

[10]

CCR8 is expressed by antigen-elicited, IL-10-producing CD4+CD25+ T cells, which regulate Th2-mediated granuloma formation in mice [J].

Freeman, CM ;

Chiu, BC ;

Stolberg, VR ;

Hu, J ;

Zeibecoglou, K ;

Lukacs, NW ;

Lira, SA ;

Kunkel, SL ;

Chensue, SW .

JOURNAL OF IMMUNOLOGY, 2005, 174 (04) :1962-1970

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