Investigation of follicular penetration of topically applied substances

被引：123

作者：

Lademann, J ^{[1
]}

Otberg, N ^{[1
]}

Richter, H ^{[1
]}

Weigmann, HJ ^{[1
]}

Lindemann, U ^{[1
]}

Schaefer, H ^{[1
]}

Sterry, W ^{[1
]}

机构：

[1] Humboldt Univ, Fac Med Charite, Dermatol Clin, Ctr Expt & Appl Cutaneous Physiol, Berlin, Germany

来源：

SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY | 2001年 / 14卷

关键词：

D O I：

10.1159/000056385

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The influence of specific follicle properties, sebum production and hair growth on the follicular penetration of topically applied substances was investigated. The behavior of follicles identified in selected skin areas of volunteers was analyzed by various tape stripping and staining methods in combination with laser scanning microscopy. Furthermore hair growth in the selected skin areas was determined. A correlation between sebum production, hair growth activity and follicular penetration was observed. Copyright (C) 2001 S.Karger AG, Basel.

引用

收藏

页码：17 / 22

页数：6

相关论文

共 7 条

[1] THE VELLUS HAIR FOLLICLE IN ACNE - HAIR-GROWTH AND SEBUM EXCRETION [J].

BLUME, U ;

VERSCHOORE, M ;

PONCET, M ;

CZERNIELEWSKI, J ;

ORFANOS, CE ;

SCHAEFER, H .

BRITISH JOURNAL OF DERMATOLOGY, 1993, 129 (01) :23-27

[2] PHYSIOLOGY OF THE VELLUS HAIR FOLLICLE - HAIR-GROWTH AND SEBUM EXCRETION [J].

BLUME, U ;

FERRACIN, J ;

VERSCHOORE, M ;

CZERNIELEWSKI, JM ;

SCHAEFER, H .

BRITISH JOURNAL OF DERMATOLOGY, 1991, 124 (01) :21-28

[3] PERCUTANEOUS-ABSORPTION OF ESTRADIOL AND PROGESTERONE IN NORMAL AND APPENDAGE-FREE SHIN OF THE HAIRLESS RAT - LACK OF IMPORTANCE OF NUTRITIONAL BLOOD-FLOW [J].

HUEBER, F ;

BESNARD, M ;

SCHAEFER, H ;

WEPIERRE, J .

SKIN PHARMACOLOGY, 1994, 7 (05) :245-256

[4] Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice [J].

Lademann, J ;

Weigmann, HJ ;

Rickmeyer, C ;

Barthelmes, H ;

Schaefer, H ;

Mueller, G ;

Sterry, W .

SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY, 1999, 12 (05) :247-256

[5] Synthesis and evaluation of N-acetylprolinate esters -: novel skin penetration enhancers [J].

Tenjarla, SN ;

Kasina, R ;

Puranajoti, P ;

Omar, MS ;

Harris, WT .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1999, 192 (02) :147-158

[6]

TUR E, 1991, SKIN PHARMACOL, V4, P230

[7] Determination of the horny layer profile by tape stripping in combination with optical spectroscopy in the visible range as a prerequisite to quantify percutaneous absorption [J].

Weigmann, HJ ;

Lademann, J ;

Meffert, H ;

Schaefer, H ;

Sterry, W .

SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY, 1999, 12 (1-2) :34-45