Pharmacokinetics and excretion of chlorogenic acid in beagle dogs

In order to characterize the pharmacokinetics and excretion of chlorogenic acid (ChA) in beagle dogs, a gradient high performance liquid chromatographic method has been developed and validated for determining ChA concentration in dog serum, urine and feces. The pharmacokinetic profile of ChA in dog after an intravenous injection was best described by a two-compartment model. Terminal half-lifes were similar at dosages of 5, 20 and 50 mg/kg, ranging from 41-45 min, while AUC and C-max values of ChA were dose proportional. There are no differences in Vd and CL at three doses of ChA, ranging from 133-252 mL/kg and from 4.4-6.3 mL/min/kg respectively. Excretion studies showed that more than 67% ChA was excreted into urine and less than 3% ChA was eliminated into feces.